Finding finer functions for partially characterized proteins by protein-protein interaction networks

Based on high-throughput data, numerous algorithms have been designed to find functions of novel proteins. However, the effectiveness of such algorithms is currently limited by some fundamental factors, including (1) the low a-priori probability of novel proteins participating in a detailed function; (2) the huge false data present in high-throughput datasets; (3) the incomplete data coverage of functional classes; (4) the abundant but heterogeneous negative samples for training the algorithms; and (5) the lack of detailed functional knowledge for training algorithms. Here, for partially characterized proteins, we suggest an approach to finding their finer functions based on protein interaction sub-networks or gene expression patterns, defined in function-specific subspaces. The proposed approach can lessen the above-mentioned problems by properly defining the prediction range and functionally filtering the noisy data, and thus can efficiently find proteins’ novel functions. For thousands of yeast and human proteins partially characterized, it is able to reliably find their finer functions (e.g., the translational functions) with more than 90% precision. The predicted finer functions are highly valuable both for guiding the follow-up wet-lab validation and for providing the necessary data for training algorithms to learn other proteins.     

层次分析法的两处缺陷改进及实例

层次分析方法在定性与定量的评判中,有较广泛地运用。在运用的过程中,发现其存在两处缺陷有待改进。其一为准则层的因素设置过于宽泛,通过其直接评判的权重存在较大的主观误差;其二为专家评判值为一定值,与实际为区间值不相符。基于此,文章提出通过第三层因素判断矩阵,来间接求取准则层各因素的权重;引入三时估算法,改进原有专家评判法,同时对三时估算值误差对权值误差以及最终评判值误差的影响作了一定程度分析。     

低热能面包的研究

本研究设计了低热能面包的综合评分法的评分标准;运用正交试验方法,优选最佳配方方案,研制出低热能面包,论述了制作工艺、流程及配方.     

合金铸铁激光处理的探讨——Ⅱ.激光辐照工艺参数的控制

用热传导方程控制激光辐照温度,建立了一种新回归方程以控制激光辐照硬化深度,选用卡尔丹公式列热传导方程及同归方程联立求解,可得到同时满足一定的硬化深度及表面最高温度双重要求的工艺参数,此种方法可作为激光硬化处理工艺参数的控制或预报,对本合金铸铁的激光硬化处理,其表面温度的下限应大于其熔点温度,即以表面产生微熔的快速冷凝处理为宜,并以选取低功率慢扫描为最佳。     

浅析地籍测量及成图方法

对目前我国地籍测量试点区测图方法进行了有代表性的具体归纳,并对其成图精度进行了比较,在此基础上分析了各种成图方法之优劣及各自适用范围,以便各种测量方法在成图过程中发挥最佳效益。     

铁路主要干线提速有关问题的研究

在对列车提速的必要性、原则和有限目标进行论述的基础上，就列车提速对运输技术设备的要求和运输组织方面的若干问题进行了初步探讨，分析了多速度客货列车混跑时，不同速度配比的组合方案对线路通过能力的影响，为干线提速的方案选定提供了基础     

熔炼数据库的建立和应用

熔炼数据库是合金熔炼多功能软件中的一个模块，本文结合作者在研究和开发软件中的体会，对建立熔炼数据库的必要性、建库过程和应用情况进行了论述．     

钢丝绳张力单片机检测系统

论述了以８０３１为控制核心的钢丝绳张力单片机检测系统的工作原理、数学模型和系统组成，重点介绍了钢丝绳张力检测的工作原理、主要硬件电路的设计特点及软件设计思想，提供了部分硬件电路图及控制软件的流程图。该系统具有置数、动态显示、数据处理、打印及人机对话等功能，并且使用方便，造价低廉。